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The only Curio you should never interact with in my opinion is the Stack of Books because you actually can't guarantee good results from those and you're much more likely to get high stress or a negative quirk than having anything positive happen.
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Who knows what value it hides Category: Cove. Darkest Dungeon Curios / Curios / Giant Oyster. However, it is worth remembering about 3 of them: Eldrich Altar - Always activate it using the Holy water, this will allow you to get rid of a negative Quirk or illness.
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As one can see, most Curio that can be found in every location are harmless and they usually offer useful items.
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